Coagulation inhibitors in alcoholic liver cirrhosis

Alcohol. 1998 Jan;15(1):19-23. doi: 10.1016/s0741-8329(97)00082-7.

Abstract

In the present study we have analyzed the relationship between coagulation inhibitors (antithrombin III, protein C and S, thrombomodulin), liver function impairment, and plasma activity of the endothelium-derived proteins plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) in 27 alcoholic cirrhotic patients and 25 controls. Cirrhotics showed decreased values of all the mentioned parameters except for thrombomodulin, PAI-1, and t-PA. Thrombomodulin and t-PA levels were higher in cirrhotics. No relationship was observed between thrombomodulin and t-PA or PAI-1. Protein C and antithrombin III levels were significantly lower in Child's C patients, whereas no correlation was found between t-PA and thrombomodulin and hepatic function derangement. PAI-1 activity was normal in our patients.

MeSH terms

  • Adult
  • Aged
  • Antithrombin III / metabolism
  • Blood Coagulation Factor Inhibitors / blood*
  • Female
  • Humans
  • Liver Cirrhosis, Alcoholic / blood*
  • Liver Cirrhosis, Alcoholic / classification
  • Male
  • Middle Aged
  • Plasminogen Activator Inhibitor 1 / metabolism
  • Protein C / metabolism
  • Protein S / metabolism
  • Thrombomodulin / blood
  • Tissue Plasminogen Activator / metabolism

Substances

  • Blood Coagulation Factor Inhibitors
  • Plasminogen Activator Inhibitor 1
  • Protein C
  • Protein S
  • Thrombomodulin
  • Antithrombin III
  • Tissue Plasminogen Activator