The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs

Genet Epidemiol. 1997;14(6):897-902. doi: 10.1002/(SICI)1098-2272(1997)14:6<897::AID-GEPI56>3.0.CO;2-H.

Abstract

This paper summarizes the results of searching for evidence of loci contributing to simulated quantitative traits which are associated with a common genetic disease using two multipoint identity by descent (IBD) sharing methods: MIM and MAPMAKER/SIBS. In brief, by varying the lod-score threshold from 1 to 3, we found that MIM and MAPMAKER/SIBS have similar power to detect linkage, but MAPMAKER/SIBS consistently produces a higher number of false positives.

Publication types

  • Comparative Study

MeSH terms

  • Chromosome Mapping / methods
  • Female
  • Genetic Linkage
  • Genetic Testing / methods*
  • Genome, Human*
  • Humans
  • Likelihood Functions
  • Lod Score
  • Male
  • Matched-Pair Analysis
  • Nuclear Family*
  • Predictive Value of Tests
  • Quantitative Trait, Heritable*
  • Software*