Identifying genetic markers to assess the presence of gene-environment interactions

Genet Epidemiol. 1997;14(6):1041-6. doi: 10.1002/(SICI)1098-2272(1997)14:6<1041::AID-GEPI80>3.0.CO;2-H.

Abstract

We analyzed a randomly chosen replicate with the goals of locating the closest markers to the genes involved in the discrete trait and utilizing these as surrogates for the genes in assessing the presence of gene-environment interactions. We screened the markers with an association test prior to using the transmission-disequilibrium test. We performed a segregation analysis, with regressive models and including the selected markers, to understand the underlying genetic mechanism and the role of the environmental factor. We were unsuccessful in locating the relevant markers due to the absence of linkage disequilibrium. Nevertheless, some insights were gained from the methods used.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Environment*
  • Evaluation Studies as Topic
  • Female
  • Genetic Markers*
  • Genetic Testing / methods*
  • Genotype
  • Humans
  • Linkage Disequilibrium*
  • Male
  • Meiosis / genetics
  • Regression Analysis

Substances

  • Genetic Markers