Cancer chemoprevention from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine: reconsideration of the evidence

Mutat Res. 1997 Nov 28;381(2):279-82. doi: 10.1016/s0027-5107(97)00220-0.
No abstract available

Publication types

  • Comment

MeSH terms

  • Animals
  • Anticarcinogenic Agents / pharmacology
  • Anticarcinogenic Agents / therapeutic use*
  • Biotransformation
  • Carcinogens / pharmacokinetics
  • Carcinogens / toxicity*
  • Cytochrome P-450 CYP1A1 / metabolism*
  • Cytochrome P-450 CYP1A2 / metabolism*
  • Diterpenes / pharmacology
  • Diterpenes / therapeutic use
  • Enzyme Induction / drug effects
  • Genotype
  • Hot Temperature
  • Humans
  • Hydroxylation
  • Imidazoles / antagonists & inhibitors*
  • Imidazoles / pharmacokinetics
  • Imidazoles / toxicity
  • Inactivation, Metabolic
  • Male
  • Meat
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology
  • Oxidation-Reduction
  • Phytotherapy
  • Rats
  • Rats, Inbred F344
  • Tea / therapeutic use

Substances

  • Anticarcinogenic Agents
  • Carcinogens
  • Diterpenes
  • Imidazoles
  • Tea
  • kahweol
  • 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • cafestol
  • Cytochrome P-450 CYP1A1
  • Cytochrome P-450 CYP1A2