Differences in pre- and post-prandial plasma lipid profiles affect the extraction efficiency of a model highly lipophilic drug from beagle dog plasma

J Pharm Biomed Anal. 1997 Sep;16(1):175-80. doi: 10.1016/s0731-7085(97)00008-3.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / blood*
  • Antimalarials / isolation & purification
  • Biological Availability
  • Chromatography, High Pressure Liquid
  • Dogs
  • Fasting / blood
  • Lipids / blood*
  • Methyl Ethers
  • Phenanthrenes / blood*
  • Phenanthrenes / isolation & purification
  • Postprandial Period
  • Solvents
  • Triglycerides / blood

Substances

  • Antimalarials
  • Lipids
  • Methyl Ethers
  • Phenanthrenes
  • Solvents
  • Triglycerides
  • methyl tert-butyl ether
  • halofantrine