Abstract
Against penicillin-susceptible pneumococci, the activity of sanfetrinem was similar to those of penicillin, amoxicillin, cefotaxime, imipenem, and meropenem, while against penicillin-resistant strains, sanfetrinem and the carbapenems exhibited superior activity (MICs at which 90% of strains are inhibited, < or =1 microg/ml). PBP 1a in the penicillin-susceptible strain and PBP 1a and PBP 2b in the more resistant isolates seemed to be the essential penicillin-binding proteins for imipenem and sanfetrinem.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / metabolism*
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Carrier Proteins / metabolism*
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Hexosyltransferases / metabolism*
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Lactams*
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Microbial Sensitivity Tests
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Multienzyme Complexes / metabolism*
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Muramoylpentapeptide Carboxypeptidase / metabolism*
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Penicillin Resistance
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Penicillin-Binding Proteins
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Peptidyl Transferases / metabolism*
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carrier Proteins
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Lactams
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Multienzyme Complexes
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Penicillin-Binding Proteins
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sanfetrinem
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Peptidyl Transferases
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Hexosyltransferases
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Muramoylpentapeptide Carboxypeptidase