Alpha-flupenthixol-induced hyperactivity by chronic dosing in rats

Eur J Pharmacol. 1976 May;37(1):169-78. doi: 10.1016/0014-2999(76)90019-4.

Abstract

Socially reared and isolation-reared rats treated chronically since weaning with alpha-flupenthixol showed elevated levels of spontaneous locomotor activity compared with control treated rats. However, chronic apomorphine treatment had no effect on spontaneous locomotor activity. Chronic alpha-flupenthixol treatment enhanced stereotyped behaviour after 1.5 mg/kg d-amphetamine or 0.5 mg/kg apomorphine in the socially reared condition. 'Spontaneous stereotypies' were also observed in the chronic alpha-flupenthixol-treated animals. Chronic apomorphine treatment did not affect stereotyped responding. The results are discussed in terms of 'behavioural supersensitivity'.

MeSH terms

  • Animals
  • Apomorphine / pharmacology
  • Body Weight / drug effects
  • Dextroamphetamine / pharmacology
  • Female
  • Flupenthixol / pharmacology*
  • Humans
  • Motor Activity / drug effects*
  • Rats
  • Social Environment
  • Social Isolation
  • Stereotyped Behavior / drug effects
  • Stimulation, Chemical
  • Thioxanthenes / pharmacology*

Substances

  • Thioxanthenes
  • Flupenthixol
  • Apomorphine
  • Dextroamphetamine