Abstract
We compared immune responses to intranasal and intramuscular DNA vaccinations against human immunodeficiency virus type 1 with monophosphoryl lipid A (MPL) used as an adjuvant. Both routes of vaccination resulted in similar levels of cell-mediated immunity, but the intestinal secretory immunoglobulin A response was higher following intranasal immunization than after intramuscular immunization. MPL demonstrated its adjuvanticity in vaccination by both routes.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
AIDS Vaccines / administration & dosage*
-
AIDS Vaccines / immunology
-
Administration, Intranasal
-
Animals
-
Cholera Toxin / administration & dosage
-
HIV Antibodies / biosynthesis
-
HIV-1 / immunology*
-
Hypersensitivity, Delayed
-
Immunity, Mucosal
-
Immunization
-
Immunoglobulin A, Secretory / biosynthesis
-
Injections, Intramuscular
-
Lipid A / administration & dosage
-
Lipid A / analogs & derivatives*
-
Mice
-
Mice, Inbred BALB C
-
Vaccines, DNA / administration & dosage*
-
Vaccines, DNA / immunology
Substances
-
AIDS Vaccines
-
HIV Antibodies
-
Immunoglobulin A, Secretory
-
Lipid A
-
Vaccines, DNA
-
Cholera Toxin
-
monophosphoryl lipid A