Objective: To demonstrate the cytochrome P450*2D6(CYP*2D6) gene polymorphism distribution in Chinese.
Methods: The polymorphisms of CYP*2D6 gene in 100 Chinese people were studied with polymerase chain reaction and Xba I restriction fragment length polymorphic (RFLP) techniques.
Results: The frequencies of CYP*2D6 gene A, B, D and E mutations were 1%, 6.5%, 0.5% and 1%, respectively; the genotypes of 29kb/29kb,44kb/29kb and 44kb/44kb Xba I RFLP were 38%, 46% and 13%, respectively. It was found that 12% of B mutations were linked with even though A and B mutations were mainly associated with 29kb/29kb genotype.
Conclusion: The frequencies of the four kinds of CYP*2D6 gene mutation in Chinese were lower than those of the European, but the frequency of Xba I 44kb allele was a little higher.