A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyltransferase

J Med Chem. 1998 Jan 15;41(2):143-7. doi: 10.1021/jm970540f.
No abstract available

MeSH terms

  • 3T3 Cells
  • Alkyl and Aryl Transferases / antagonists & inhibitors*
  • Animals
  • Antineoplastic Agents / therapeutic use
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Farnesyltranstransferase
  • Female
  • Mice
  • Mice, Nude
  • Models, Chemical
  • Neoplasm Transplantation
  • Neoplasms, Experimental / drug therapy
  • Polyisoprenyl Phosphates / chemistry*
  • Polyisoprenyl Phosphates / pharmacology
  • Sesquiterpenes
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Polyisoprenyl Phosphates
  • Sesquiterpenes
  • farnesyl pyrophosphate
  • Alkyl and Aryl Transferases
  • Farnesyltranstransferase