Assignment of the human fast skeletal muscle troponin C gene (TNNC2) between D20S721 and GCT10F11 on chromosome 20 by somatic cell hybrid analysis

P J Townsend; M H Yacoub; P J Barton

doi:10.1046/j.1469-1809.1997.6150457.x

Assignment of the human fast skeletal muscle troponin C gene (TNNC2) between D20S721 and GCT10F11 on chromosome 20 by somatic cell hybrid analysis

Ann Hum Genet. 1997 Sep;61(Pt 5):457-9. doi: 10.1046/j.1469-1809.1997.6150457.x.

Authors

P J Townsend¹, M H Yacoub, P J Barton

Affiliation

¹ Imperial College School of Medicine, National Heart and Lung Institute, London.

PMID: 9459007
DOI: 10.1046/j.1469-1809.1997.6150457.x

Abstract

The chromosomal location of the human fast skeletal muscle troponin C (TNNC2) gene was determined using somatic cell hybrids. PCR-based analysis of a 'monochromosomal' hybrid panel identified the presence of the TNNC2 gene on human chromosome 20 and subsequent analysis of the Genebridge4 radiation hybrid panel located the gene between D20S721 and GCT10F11 with a lod score of > 3.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping
Chromosomes, Human, Pair 20 / genetics*
DNA / analysis
Genetic Markers
Humans
Hybrid Cells / chemistry*
Muscle Fibers, Fast-Twitch / chemistry*
Polymerase Chain Reaction
Troponin C / genetics*

Substances

Genetic Markers
Troponin C
DNA