We described the clinical feature of cytomegalovirus(CMV) infection, its epidemiology, and prognosis of congenital CMV infection. Then, the anti-viral treatment with the ganciclovir against the congenital CMV infection was discussed. We showed that the presence of CMV-DNA in the plasma was useful to determine the indication of the therapy. We also showed our case of chronic active Epstein-Barr virus infection to introduce the adoptive immune therapy as a new strategy for the treatment of severe virus infections. Lastly, application of this therapy for the CMV infection in overseas and its future prospect were described.