Abstract
A series of novel flavonoids comprising structural elements present in the antineoplastic agents podophyllotoxin and etoposide was synthesized. These oxygen-containing analogues of antiproliferative quinolones moderate cytotoxicity towards L1210 and HT-29 cell lines.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibiotics, Antineoplastic / pharmacology
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Antineoplastic Agents, Phytogenic / chemical synthesis*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Division / drug effects
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Doxorubicin / pharmacology
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Etoposide / chemistry
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Flavanones*
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Flavonoids / chemical synthesis*
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Flavonoids / pharmacology
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Humans
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Keratolytic Agents / chemical synthesis*
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Keratolytic Agents / pharmacology
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Podophyllotoxin / chemistry*
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Tumor Cells, Cultured / drug effects
Substances
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Antibiotics, Antineoplastic
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Antineoplastic Agents, Phytogenic
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Flavanones
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Flavonoids
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Keratolytic Agents
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Etoposide
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Doxorubicin
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Podophyllotoxin
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flavanone