Structure and function of heparin-binding EGF-like growth factor (HB-EGF)

K M Davis-Fleischer; G E Besner

doi:10.2741/a241

Structure and function of heparin-binding EGF-like growth factor (HB-EGF)

Front Biosci. 1998 Mar 1:3:d288-99. doi: 10.2741/a241.

Authors

K M Davis-Fleischer¹, G E Besner

Affiliation

¹ Department of Surgery, Children's Hospital and The Ohio State University, 700 Children's Drive, Columbus, Ohio 43205, USA.

PMID: 9473209
DOI: 10.2741/a241

Abstract

Heparin-binding EGF-like growth factor (HB-EGF) is a 22 kDa, O-glycosylated protein that is mitogenic for fibroblasts, smooth muscle cells (SMC) and epithelial cells. This review describes the primary structure of HB-EGF, as well as its processing. The structure of the mouse and human HB-EGF genes is also discussed. Finally, this review summarizes HB-EGF expression patterns, receptor-mediated signaling, and role in several important biological systems.

Publication types

Review

MeSH terms

Amino Acid Sequence
Animals
Epidermal Growth Factor / chemistry*
Epidermal Growth Factor / physiology*
Heparin-binding EGF-like Growth Factor
Humans
Intercellular Signaling Peptides and Proteins
Molecular Sequence Data

Substances

HBEGF protein, human
Hbegf protein, mouse
Heparin-binding EGF-like Growth Factor
Intercellular Signaling Peptides and Proteins
Epidermal Growth Factor