Abstract
We report the cloning and characterization of a novel cDNA termed C2H2-546 which encodes a C2H2-type zinc finger protein. C2H2-546 RNA is expressed in the HTLV-1 infected T cells examined which were derived from HAM-TSP patients, but not in T cells derived from ATL patients. The C2H2-546 gene is conserved in humans and primates and maps to chromosome 10q11.2, a site associated with a variety of cancers. Thus, C2H2-546 is a candidate regulatory molecule important in the formation of these tumors, and may serve as an important marker to distinguish HTLV-1 infected ATL versus HAM-TSP T cell lineages.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Chromosomes, Artificial, Yeast
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Chromosomes, Human, Pair 10 / genetics*
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DNA, Complementary / genetics
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Drosophila melanogaster / genetics
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Gene Expression Regulation, Viral*
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Genes*
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HTLV-I Infections / genetics*
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Human T-lymphotropic virus 1 / physiology*
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Humans
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Kruppel-Like Transcription Factors
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Leukemia-Lymphoma, Adult T-Cell / genetics
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Leukemia-Lymphoma, Adult T-Cell / pathology
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Mammals / genetics
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Molecular Sequence Data
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Neoplasm Proteins / biosynthesis
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Neoplasm Proteins / genetics*
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Nuclear Proteins
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Paraparesis, Tropical Spastic / genetics
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Paraparesis, Tropical Spastic / pathology
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Polymerase Chain Reaction
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Saccharomyces cerevisiae / genetics
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Species Specificity
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T-Lymphocytes / metabolism*
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T-Lymphocytes / virology
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Transcription Factors
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Tumor Cells, Cultured
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Zinc Fingers / genetics*
Substances
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DNA, Complementary
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Kruppel-Like Transcription Factors
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Neoplasm Proteins
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Nuclear Proteins
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Transcription Factors
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ZNF32 protein, human