GM1 ganglioside potentiates trimethyltin-induced expression of interleukin-1 beta and the nerve growth factor in reactive astrocytes in the rat hippocampus: an immunocytochemical study

Neurochem Res. 1998 Mar;23(3):443-53. doi: 10.1023/a:1022482106152.

Abstract

This study demonstrates potentiation by GM1 ganglioside treatment of trimethyltin (TMT) induced reactivity of astrocytes, and the expression of astroglial interleukin-1 beta (IL-1 beta) and nerve growth factor (NGF) immunoreactivities in the rat hippocampus. GM1 treatment also results in an increase of the number of IL-1 beta and NGF immunoreactive astrocytes. Both the intensity of gliosis and stimulation of IL-1 beta and NGF expression in astrocytes mostly occurs in the regions of heaviest neurodegeneration in the hippocampus (CA4/CA3c and CA1). It is tempting to assume that enhancement of astroglial NGF expression by GM1 ganglioside may play a role in the protective action of GM1 against neurotoxic insult.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Astrocytes / chemistry
  • Astrocytes / drug effects
  • Astrocytes / metabolism*
  • Drug Synergism
  • G(M1) Ganglioside / administration & dosage*
  • Hippocampus / chemistry
  • Hippocampus / drug effects
  • Hippocampus / metabolism*
  • Immunohistochemistry
  • Injections, Intramuscular
  • Injections, Intraperitoneal
  • Interleukin-1 / analysis
  • Interleukin-1 / biosynthesis*
  • Male
  • Nerve Growth Factors / analysis
  • Nerve Growth Factors / biosynthesis*
  • Nerve Growth Factors / drug effects*
  • Rats
  • Rats, Wistar
  • Trimethyltin Compounds / administration & dosage*

Substances

  • Interleukin-1
  • Nerve Growth Factors
  • Trimethyltin Compounds
  • G(M1) Ganglioside
  • trimethyltin chloride