Objective: To report a case of clozapine-induced hypertension with raised urinary catecholamines.
Clinical picture: A 27-year-old man fulfilling DSM-III-R criteria for catatonic schizophrenia was treated with clozapine. He later developed both hypertension and raised urinary catecholamines which mimicked phaeochromocytoma.
Treatment: Clozapine was withdrawn.
Outcome: Both blood pressure and urinary catecholamines normalised.
Conclusions: Clozapine may induce sympathetic hyperactivity.