Eight partially irradiated oral cancer patients were treated using either mandibular implant and mucosa-supported telescopic coping prostheses or a restoration that was completely implant-supported with telescopic copings. Both types of restorations provided sufficient positional stability and peri-implant hygiene, and functional and esthetic improvement. However, only the completely implant-supported telescopic prosthesis avoided soft tissue ulcers that had the potential for the development of osteoradionecrosis. This type of restoration can especially be recommended for irradiated patients.