Identification of epitopes of fibronectin attachment protein (FAP-A) of Mycobacterium avium which stimulate strong T-cell responses in mice

Infect Immun. 1998 Mar;66(3):1261-4. doi: 10.1128/IAI.66.3.1261-1264.1998.

Abstract

The T-cell response to fibronectin attachment protein (FAP-A) in BALB/c and B10.BR mice was examined. Both strains developed strong T-cell responses to FAP-A, directed to single, unique epitopes. T cells from mice infected with Mycobacterium avium responded to FAP-A, suggesting a possible role in a protective immune response.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adhesins, Bacterial*
  • Amino Acid Sequence
  • Animals
  • Bacterial Proteins / immunology*
  • Carrier Proteins / immunology*
  • Epitopes*
  • Lymphocyte Activation*
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Mycobacterium tuberculosis / immunology*
  • T-Lymphocytes / immunology*

Substances

  • Adhesins, Bacterial
  • Bacterial Proteins
  • Carrier Proteins
  • Epitopes
  • fibronectin-binding proteins, bacterial