Heat shock inducibility of an archaeal TATA-like promoter is controlled by adjacent sequence elements

Mol Microbiol. 1998 Feb;27(3):541-51. doi: 10.1046/j.1365-2958.1998.00698.x.

Abstract

The expression of a heat-inducible cct1 (chaperonin-containing Tcp-1) family member gene is regulated at the transcription level in the archaeon Haloferax volcanii. Transcriptional fusions of the cct1 promoter region with a yeast proline tRNA reporter gene were constructed to analyse the functional domains of this archaeal heat shock promoter. Both basal and heat-induced transcription of the reporter gene was directed by an archaeal consensus TATA element (5'-TTTATA-3') centred 25bp upstream of the transcription start site. Deletion mutagenesis indicated that the 5' boundary of the cct1 regulatory region mapped to position -37. Nucleotide alignment with the 5' flanking regions of two additional cct-related genes identified in H. volcanii showed a high degree of sequence conservation between positions +1 and -37, especially in and immediately surrounding the TATA element of the putative core promoter. Mutational analysis of conserved sequences demonstrated that basal and heat-induced transcription required sequence elements located upstream and downstream of the TATA-box. These findings indicate that the regulatory sequences involved in heat-induced transcription lie within the core promoter region and suggest that the mechanism controlling heat shock gene expression in H. volcanii differs from the bacterial and eukaryal strategies.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Archaeal Proteins*
  • Artificial Gene Fusion
  • Base Sequence
  • Conserved Sequence
  • DNA Mutational Analysis
  • Gene Deletion
  • Gene Expression Regulation, Archaeal*
  • Genes, Archaeal
  • Genes, Reporter
  • Haloferax volcanii / chemistry
  • Haloferax volcanii / genetics*
  • Haloferax volcanii / metabolism
  • Heat-Shock Proteins / genetics*
  • Heat-Shock Response
  • Hot Temperature*
  • Molecular Chaperones / genetics*
  • Molecular Sequence Data
  • Mutagenesis
  • Promoter Regions, Genetic*
  • TATA Box*
  • Transcription, Genetic

Substances

  • Archaeal Proteins
  • Heat-Shock Proteins
  • Molecular Chaperones

Associated data

  • GENBANK/AF029873