Abstract
This is a case report of a ten year old girl with ovarian germ cell tumor who was successfully treated with BEP chemotherapy. She developed acute myloid leukemia, AML-M5 with t(11;19)(q23;p13), 29 months after being off therapy. She received a cumulative dose of 2000 mg/m2 of etoposide and 400 mg/m2 of cisplatin. The association of etoposide and therapy related leukemia is reviewed.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Child
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Chromosomes, Human, Pair 11*
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Chromosomes, Human, Pair 19
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Cisplatin / administration & dosage
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Etoposide / administration & dosage
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Female
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Germinoma / complications
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Germinoma / drug therapy*
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Germinoma / genetics
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Humans
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Leukemia, Myeloid, Acute / chemically induced*
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Leukemia, Myeloid, Acute / genetics
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Ovarian Neoplasms / complications
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Ovarian Neoplasms / drug therapy*
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Ovarian Neoplasms / genetics
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Translocation, Genetic*