Pharmacological screening of different Juniperus oxycedrus L. extracts

Pharmacol Toxicol. 1998 Feb;82(2):108-12. doi: 10.1111/j.1600-0773.1998.tb01407.x.

Abstract

Methanol and dichloromethanol extracts of leaves and stems of Juniperus oxycedrus have been tested for their toxicity, analgesic, antiinflammatory and central effects. Both extracts showed low acute toxicity and decreased spontaneous motility. The methanol extract exhibited an analgesic effect in models of chemical, mechanical and thermal stimulation whereas dichloromethanol extract showed only a significant effect in models of pain induced by chemical stimulation. Both extracts showed a significant antiinflammatory activity and inhibition of the rat paw oedema induced by carrageenin.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Inflammation / drug therapy
  • Juniperus* / chemistry
  • Juniperus* / therapeutic use
  • Male
  • Methanol
  • Mice
  • Motor Activity / drug effects
  • Pain Threshold / drug effects*
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Wistar

Substances

  • Plant Extracts
  • Methanol