Abstract
RB1BUS6lacgpt, a Marek's disease virus (MDV) mutant having a disrupted glycoprotein D (gD) homolog gene, established infection and induced tumors in chickens exposed to it by inoculation or by contact. Lymphoblastoid cell lines derived from RB1BUS6lacgpt-induced tumors harbored only the mutant virus. These results provide strong evidence that an intact gD homolog gene is not essential for oncogenicity or horizontal transmission of MDV.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Bacterial Proteins / genetics
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Cell Transformation, Viral*
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Chickens
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Cloning, Molecular
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Disease Transmission, Infectious*
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Escherichia coli Proteins
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Gene Expression
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Herpesvirus 2, Gallid / genetics
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Herpesvirus 2, Gallid / isolation & purification
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Herpesvirus 2, Gallid / metabolism
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Herpesvirus 2, Gallid / pathogenicity*
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Lac Operon
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Lymphoma
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Marek Disease / transmission*
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Marek Disease / virology
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Mutagenesis, Insertional
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Pentosyltransferases
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Proteins*
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RNA, Viral
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Tumor Cells, Cultured
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Viral Envelope Proteins / genetics
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Viral Envelope Proteins / physiology*
Substances
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Bacterial Proteins
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Escherichia coli Proteins
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Proteins
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RNA, Viral
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Viral Envelope Proteins
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glycoprotein D, Marek's disease virus
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Pentosyltransferases
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Gpt protein, E coli