Abstract
Twenty-five genes have been identified in which mutations cause epileptic seizures in mice. The gene for a Na+/H+ exchanger has recently been found to underlie the spontaneous mutant slow wave epilepsy. Studies of such mutants should help elucidate the mechanisms that control neuronal excitability.
Publication types
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Review
MeSH terms
-
Animals
-
Disease Models, Animal
-
Epilepsy / genetics*
-
Mice
-
Mice, Mutant Strains
-
Mutation*
-
Sodium-Hydrogen Exchangers / genetics
-
Sodium-Hydrogen Exchangers / physiology
Substances
-
Sodium-Hydrogen Exchangers
-
growth factor-activatable Na-H exchanger NHE-1