Percutaneous transluminal coronary angioplasty was performed on 2 patients, each having an anomalous origin of the right coronary artery with anterior-superior orientation. Each patient had experienced post-infarction angina after an inferior wall myocardial infarction without antecedent thrombolytic therapy. The procedures were successfully performed with appropriate selection and manipulation of the guiding catheter. Our findings indicate that the Amplatz left catheter is the guiding catheter of choice in catheterizing a right coronary artery of anomalous origin with anterior-superior orientation.