Abstract
The cyclization of ester thiosemicarbazones to two different heterocycles was studied for some new thiosemicarbazones, and only the formation of 1,2,4-triazol-5-thiols was attributed to the regioselectivity of the ring closure reaction, due to a steric hindrance of bulky groups. Next, some of the new compounds were tested for their in vitro antimicrobial and antitumor activities.
MeSH terms
-
Antibiotics, Antitubercular / chemical synthesis*
-
Antibiotics, Antitubercular / pharmacology
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / pharmacology
-
Gram-Negative Bacteria / drug effects
-
Gram-Positive Bacteria / drug effects
-
Thiosemicarbazones / chemical synthesis*
-
Thiosemicarbazones / pharmacology
-
Triazoles / chemical synthesis
-
Triazoles / pharmacology
-
Tumor Cells, Cultured / drug effects
Substances
-
3-(4-chlorobenzyl)-1,2,4-triazol-5-thiol
-
3-(4-methylbenzyl)-1,2,4-triazol-5-thiol
-
Antibiotics, Antitubercular
-
Antineoplastic Agents
-
Thiosemicarbazones
-
Triazoles
-
ethyl 4-chlorophenylacetate thiosemicarbazone
-
ethyl 4-methylphenylacetate thiosemicarbazone