Cellular senescence: lessons from yeast for human aging?

Curr Biol. 1998 Mar 12;8(6):R192-5. doi: 10.1016/s0960-9822(98)70122-8.

Abstract

Recent results point to an important role for the nucleolus in the senescence of yeast cells. A further report suggests that the formation and preferential accumulation in mother cells of extrachromosomal rDNA circles is a cause of aging in yeast; this may be an ancient and conserved mechanism of senescence.

Publication types

  • Review

MeSH terms

  • Aging*
  • Cell Nucleolus / genetics
  • Cellular Senescence / genetics*
  • DNA-Binding Proteins / biosynthesis
  • DNA-Binding Proteins / physiology
  • Extrachromosomal Inheritance / genetics
  • Fungal Proteins / physiology
  • Humans
  • Saccharomyces cerevisiae / physiology*
  • Telomere / genetics
  • Trans-Activators / physiology

Substances

  • DNA-Binding Proteins
  • Fungal Proteins
  • Trans-Activators