Abstract
Recent results point to an important role for the nucleolus in the senescence of yeast cells. A further report suggests that the formation and preferential accumulation in mother cells of extrachromosomal rDNA circles is a cause of aging in yeast; this may be an ancient and conserved mechanism of senescence.
MeSH terms
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Aging*
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Cell Nucleolus / genetics
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Cellular Senescence / genetics*
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DNA-Binding Proteins / biosynthesis
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DNA-Binding Proteins / physiology
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Extrachromosomal Inheritance / genetics
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Fungal Proteins / physiology
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Humans
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Saccharomyces cerevisiae / physiology*
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Telomere / genetics
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Trans-Activators / physiology
Substances
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DNA-Binding Proteins
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Fungal Proteins
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Trans-Activators