Abstract
The pleiotropic biological activities of interleukin-18 (IL-18) are mediated by IL-18 receptor (IL-18R). When the ligand binds to the IL-18R, IL-18R initiates a signaling cascade that results in the activation of nuclear factor kappa B (NF-kappa B). When mouse EL-4 cells were exposed to IL-18, IL-1 receptor-associated kinase (IRAK) was recruited to IL-18R and was phosphorylated. In addition, tumor necrosis factor receptor-associated factor-6 (TRAF6) was associated with IRAK. Therefore, we concluded that IL-18/IL-18R-mediated signaling may share the IRAK/TRAF6 pathway through NF-kappa B activation with the IL-1/IL-1 receptor system.
MeSH terms
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Animals
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Carrier Proteins / metabolism*
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Carrier Proteins / physiology
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Cytokines / metabolism
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Cytokines / pharmacology*
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Enzyme Activation
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Interleukin-1 Receptor-Associated Kinases
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Interleukin-18
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Interleukins / metabolism
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Interleukins / pharmacology*
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Mice
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NF-kappa B / metabolism
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Protein Kinases / metabolism*
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Protein Kinases / physiology
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Proteins*
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Receptors, Interleukin-1 / metabolism*
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Receptors, Interleukin-1 / physiology
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Receptors, Tumor Necrosis Factor / metabolism
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Signal Transduction / drug effects
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T-Lymphocytes / enzymology
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T-Lymphocytes / metabolism
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TNF Receptor-Associated Factor 6
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Thymoma
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Tumor Cells, Cultured
Substances
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Carrier Proteins
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Cytokines
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Interleukin-18
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Interleukins
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NF-kappa B
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Proteins
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Receptors, Interleukin-1
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Receptors, Tumor Necrosis Factor
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TNF Receptor-Associated Factor 6
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Protein Kinases
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Interleukin-1 Receptor-Associated Kinases