Abstract
Comparisons of the biological activities of diosgenyl, methyl glycyrrhetinate, or digitoxigenyl 3-O-beta-D-glucopyranosyl-(1-->2)-alpha-D-glucopyranoside with those of other previously tested glycosides confirmed our assumption that both haemolytic and antifungal activities of steroid saponins are generally parallel to each other, while almost all haemolytic triterpenoid saponins have no antifungal activity. The earlier supposition that cardiac diglycosides having a (1-->4) sugar linkage have stronger activities than those with a (1-->6) linkage has been extended by the demonstration of reduced activity also in those with a (1-->2) linkage.
MeSH terms
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Adenosine Triphosphatases / antagonists & inhibitors
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Antiviral Agents / pharmacology
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Carbohydrate Conformation
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Cardiac Glycosides / chemistry
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Enzyme Inhibitors / pharmacology
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Glycosides / chemical synthesis
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Glycosides / chemistry
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Glycosides / pharmacology
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Hemolysis*
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Microbial Sensitivity Tests
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Molecular Structure
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Saponins / chemical synthesis
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Saponins / chemistry
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Saponins / pharmacology*
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Steroids / chemical synthesis
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Steroids / chemistry
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Steroids / pharmacology*
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Structure-Activity Relationship
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Triterpenes / chemical synthesis
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Triterpenes / chemistry
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Triterpenes / pharmacology*
Substances
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Antifungal Agents
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Antiviral Agents
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Cardiac Glycosides
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Enzyme Inhibitors
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Glycosides
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Saponins
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Steroids
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Triterpenes
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Adenosine Triphosphatases