Abstract
The immediate-early gene ie14/vsag of herpesvirus saimiri has homology with murine superantigens. We compared the pathogenesis of infection with either ie14/vsag deletion mutants or wild-type virus C488 in cottontop tamarin monkeys (Saguinus oedipus). Two weeks after infection, all animals developed acute T-cell lymphomas independently of the presence of the viral ie14/vsag gene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Viral / genetics
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Antigens, Viral / physiology*
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Gene Deletion
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Genes, Viral*
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Herpesviridae Infections / pathology
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Herpesviridae Infections / virology*
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Herpesvirus 2, Saimiriine / genetics
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Herpesvirus 2, Saimiriine / physiology*
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Humans
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Lymphoma, T-Cell / pathology
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Lymphoma, T-Cell / virology*
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Saguinus
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Superantigens / genetics
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Superantigens / physiology*
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Tumor Virus Infections / pathology
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Tumor Virus Infections / virology*
Substances
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Antigens, Viral
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Superantigens