Abstract
Twenty-three patients enrolled in th GUSTO-III study underwent serial measurements of soluble vascular cell adhesion molecule-1 (VCAM-1) and E-selectin by enzyme-linked immunosorbent assay at prespecified time intervals. Soluble VCAM-1, but not E-selectin levels, were increased in patients with acute myocardial infarction, indicating that VCAM-1 may serve as a marker of increased endothelial activation in acute myocardial infarction.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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E-Selectin / blood*
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Female
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Fibrinolytic Agents / therapeutic use
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Humans
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Male
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Middle Aged
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Myocardial Infarction / blood*
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Myocardial Infarction / drug therapy*
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Plasminogen Activators / therapeutic use
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Recombinant Proteins / therapeutic use
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Thrombolytic Therapy*
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Time Factors
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Tissue Plasminogen Activator / therapeutic use
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Vascular Cell Adhesion Molecule-1 / blood*
Substances
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E-Selectin
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Fibrinolytic Agents
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Recombinant Proteins
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Vascular Cell Adhesion Molecule-1
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reteplase
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Plasminogen Activators
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Tissue Plasminogen Activator