The Authors have appraised, in a group of 20 patients suffering from "non-ulcer, non-reflux dyspepsia", the therapeutical action and tolerance of the oligomineral Santa Croce water from the Sponga spring administered at a dose of 500 mL with the main meals up to an overall quantity of 1.5 L per day for ten days. When compared with a comparable control group, taking fairly mineralized water of known composition and free of contaminants, the group of patients treated showed a significant reduction both in the number and intensity of the symptoms marking the dyspeptic condition including above all pyrosis and sensation of epigastric heaviness and laborious digestion. As a first hypothesis, the hydropinic treatment might have indirectly favoured post-prandial gastric emptying, through an action of reduction of endogastric osmolarity and pH. The only collateral effect, reported by only five subjects, consisted of an annoying pollakiuria and nycturia.