Abstract
Changes in antibiotic susceptibility was evaluated in 77 consecutive nosocomial clinical isolates of Staphylococcus aureus collected from 1986 to 1994 at the Umberto I Polyclinic of the University of Rome (63 isolates) and from 7 other Roman hospitals (14 isolates). Oxacillin resistance in these isolates increased from 39% during the 1980s to 69% during the 1990s. Significant increases in resistance to ciprofloxacin, clindamycin and rifampicin were observed among oxacillin-resistant strains. No resistance to glycopeptides was observed although both teicoplanin and vancomycin had slightly reduced antistaphylococcal activity.
MeSH terms
-
Anti-Bacterial Agents
-
Anti-Infective Agents / pharmacology*
-
Antibiotics, Antitubercular / pharmacology*
-
Ciprofloxacin / pharmacology
-
Clindamycin / pharmacology
-
Cross Infection / microbiology
-
Drug Resistance, Microbial
-
Glycopeptides
-
Humans
-
Italy
-
Oxacillin / pharmacology
-
Penicillins / pharmacology*
-
Rifampin / pharmacology
-
Serum Bactericidal Test
-
Staphylococcal Infections / microbiology
-
Staphylococcus aureus / drug effects*
-
Staphylococcus aureus / isolation & purification
Substances
-
Anti-Bacterial Agents
-
Anti-Infective Agents
-
Antibiotics, Antitubercular
-
Glycopeptides
-
Penicillins
-
Clindamycin
-
Ciprofloxacin
-
Oxacillin
-
Rifampin