Abstract
A novel antifungal antibiotic GR135402 has been isolated from a fermentation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The spectrum of activity included C. albicans and Cryptococcus neoformans but not some other Candida species or Aspergillus species. Therapeutic efficacy in a mouse model of systemic candidosis was attained following parenteral dosing.
MeSH terms
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Animals
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Antifungal Agents / chemistry*
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Aspergillus / drug effects
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Candida albicans / drug effects
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Fermentation
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Mice
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Microbial Sensitivity Tests
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Mitosporic Fungi / chemistry*
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Mitosporic Fungi / classification
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Polycyclic Compounds / chemistry*
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Polycyclic Compounds / isolation & purification*
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Polycyclic Compounds / pharmacology
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Protein Synthesis Inhibitors / chemistry*
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Protein Synthesis Inhibitors / isolation & purification*
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Protein Synthesis Inhibitors / pharmacology
Substances
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Antifungal Agents
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GR135402
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Polycyclic Compounds
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Protein Synthesis Inhibitors