Analysis of vessel wall morphology, blood flow velocity, and the hemostatic system in a patient with a large intracoronary thrombus

Cathet Cardiovasc Diagn. 1998 Mar;43(3):298-305. doi: 10.1002/(sici)1097-0304(199803)43:3<298::aid-ccd12>3.0.co;2-i.

Abstract

A patient with AMI caused by a large thrombus in the proximal LAD was successfully treated with PTCA and an intracoronary lysis combined with the platelet-receptor antagonist c7E3. Analysis of cellular hemostasis after 1 and 6 months revealed a sustained platelet activation despite combined anti-platelet therapy with ASA and ticlopidine. A progredient slow-flow phenomenon appeared during control angiographies, confirmed by intracoronary Doppler examination.

Publication types

  • Case Reports

MeSH terms

  • Abciximab
  • Adult
  • Angioplasty, Balloon, Coronary
  • Antibodies, Monoclonal / therapeutic use
  • Blood Coagulation / drug effects
  • Blood Flow Velocity
  • Coronary Angiography*
  • Coronary Circulation* / drug effects
  • Coronary Thrombosis / complications
  • Coronary Thrombosis / diagnosis*
  • Coronary Thrombosis / physiopathology
  • Coronary Thrombosis / therapy
  • Flow Cytometry
  • Follow-Up Studies
  • Humans
  • Immunoglobulin Fab Fragments / therapeutic use
  • Male
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / etiology
  • Myocardial Infarction / therapy
  • Platelet Activation* / drug effects
  • Platelet Aggregation Inhibitors / therapeutic use
  • Thrombolytic Therapy
  • Ultrasonography, Interventional*
  • Vascular Patency

Substances

  • Antibodies, Monoclonal
  • Immunoglobulin Fab Fragments
  • Platelet Aggregation Inhibitors
  • Abciximab