The aim of this study was to use transcutaneous oxygen pressure (tcpO2) measurements to evaluate the efficacy of a solution containing hyper-oxygenated fatty acid esters in the prevention of pressure sores in 28 patients at high risk of developing sores. Statistical analysis indicates a significant difference between tcpO2 values during pressure exertion before and after application of the product (p = 0.014). Oxygen pressure values decreased significantly when the patient applied pressure to the sacral area before the test product was applied whereas no difference in oxygen pressure values was noted after application of the test product.