Abstract
Trichoflectin (1), a new azaphilone belonging to the deflectin series, 6-deoxy-7-0-demethyl-3,4-anhydrofusarubin (2), and 6-deoxy-3,4-anhydrofusarubin (3) were isolated from submerged cultures of the ascomycete Trichopezizella nidulus. All compounds showed antimicrobial activity and inhibited dihydroxynaphthalene melanin biosynthesis in fungi. The structure of trichoflectin (1) was elucidated by spectroscopic methods.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Ascomycota / chemistry*
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Ascomycota / metabolism
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Bacillus subtilis
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Benzopyrans / isolation & purification*
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Benzopyrans / pharmacology
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Chromatography, High Pressure Liquid
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Mucor / drug effects
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Benzopyrans
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trichoflectin