Abstract
The checkerboard method was used to determine the antimicrobial activity of the combination cefotaxime/ofloxacin against 217 bacterial isolates involved in serious infections. Synergy or partial synergy was observed against 19 of 34 (55.8%) Staphylococcus aureus methicillin-susceptible isolates, 4 of 47 (8.4%) Streptococcus pneumoniae isolates, 28 of 34 (82.2%) Escherichia coli isolates and 70 of 102 (68.5%) Pseudomonas aeruginosa isolates. Antagonism was not observed with any of the isolates examined.
MeSH terms
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / pharmacology*
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Bacterial Infections / microbiology*
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Cefotaxime / administration & dosage
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Cefotaxime / pharmacology*
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Cephalosporin Resistance
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Cephalosporins / administration & dosage
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Cephalosporins / pharmacology*
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Dose-Response Relationship, Drug
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Drug Interactions
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Drug Resistance, Microbial
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Drug Resistance, Multiple
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Drug Synergism
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Gram-Negative Bacteria / drug effects*
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Gram-Positive Bacteria / drug effects*
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Humans
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Microbial Sensitivity Tests
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Ofloxacin / administration & dosage
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Ofloxacin / pharmacology*
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Species Specificity
Substances
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Anti-Infective Agents
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Cephalosporins
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Ofloxacin
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Cefotaxime