Germicidal agents used as antiseptics and disinfectants play an important role in the control of infection in the veterinary patient. Critical to the proper use of germicidal agents in or around the veterinary patient is knowledge of efficacy and contraindications. The key to proper use of antiseptics and disinfectants is using the proper germicidal agent under conditions that maximize success and minimize complications. Although there are a number of germicidal agents commercially available, effective antisepsis and disinfection can be achieved through use of a few effective, yet safe germicides.