In 1994, the Iowa Farm Family Health and Hazard Surveillance Project carried out a two-stage, stratified, cluster survey of Iowa farms using a mail survey. With data from this representative sample of Iowa farmers, we examined the associations between farm-work-related injuries and possible risk factors for 390 principal farm operators. Forty (10.3%) of these operators reported being injured while doing farm work. We developed a logistic regression to assess associations between potential risk factors and injury. We found three factors significantly associated with injury: younger age (odds ratio [OR] = 3.1, confidence interval [CI] = 1.1-9.3), having an impairment or health problem that limits work (OR = 2.4, CI = 1.5-3.8), and hand or arm exposure to acids or alkalis (OR = 2.6, CI = 1.1-5.9). In the univariate analysis, safety training did not seem to protect farmers from injuries.