Abstract
Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patients.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Infective Agents / therapeutic use*
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Mice
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Mice, Inbred BALB C
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Pneumonia, Pneumocystis / drug therapy*
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Rats
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Sulfamethoxypyridazine / therapeutic use*
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Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
Substances
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Anti-Infective Agents
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Trimethoprim, Sulfamethoxazole Drug Combination
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Sulfamethoxypyridazine