Clinic modelling randomised trials (CMRT's) in animals as a new intermediate between biological experiments and randomised clinical trials: application to antihistamine prophylaxis in anaesthesia and surgery

Inflamm Res. 1998:47 Suppl 1:S66-8. doi: 10.1007/s000110050277.

Authors

I Celik¹, W Lorenz, B Stinner, D Duda, H Sitter, S Sauer, A Junge, M Hoppe

Affiliation

¹ Institute of Theoretical Surgery, Philipps University, Marburg, Germany.

PMID: 9561420
DOI: 10.1007/s000110050277

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anesthesia / adverse effects
Animals
Cimetidine / administration & dosage
Cimetidine / therapeutic use
Dimethindene / administration & dosage
Dimethindene / therapeutic use
Disease Models, Animal*
Double-Blind Method
Female
Histamine H1 Antagonists / administration & dosage
Histamine H1 Antagonists / therapeutic use*
Histamine H2 Antagonists / administration & dosage
Histamine H2 Antagonists / therapeutic use*
Histamine Release / drug effects
Intraoperative Complications / prevention & control*
Male
Premedication
Randomized Controlled Trials as Topic*
Ranitidine / administration & dosage
Ranitidine / therapeutic use
Surgical Procedures, Operative / adverse effects
Swine
Swine, Miniature
p-Methoxy-N-methylphenethylamine

Substances

Histamine H1 Antagonists
Histamine H2 Antagonists
p-Methoxy-N-methylphenethylamine
Dimethindene
Cimetidine
Ranitidine