Abstract
Fifty-eight of 89 serum samples (65.17%) from HIV-1-infected individuals at various disease stages contain antibodies that react with a platelet peptide located in the cytoplasmic domain of integrin beta3, glycoprotein GPIIIa (aa749-761; sequence DRKEFAKFEEERA). Rabbit polyclonal antibodies raised against the synthetic platelet peptide also react with the structurally homologous HIV-1 gp41-derived peptide (EKNEQELLELDKW(A)) and bind to a Western blot band with molecular weight corresponding to HIV-1 gp41. These findings point to molecular mimicry between HIV-1 and a human membrane protein found in platelets and other cells that could be of pathologic consequence.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Helminth / immunology
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Antigens, CD / chemistry
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Antigens, CD / genetics*
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Antigens, CD / immunology
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Antigens, Helminth / chemistry
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Antigens, Helminth / immunology
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Blotting, Western
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Cysticercosis / immunology
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Enzyme-Linked Immunosorbent Assay
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Epitopes / chemistry
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Epitopes / genetics
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Epitopes / immunology
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HIV Antibodies / blood
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HIV Antibodies / immunology
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HIV Envelope Protein gp41 / chemistry
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HIV Envelope Protein gp41 / genetics*
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HIV Envelope Protein gp41 / immunology
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HIV Infections / blood
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HIV Infections / immunology
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HIV Seropositivity / immunology
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HIV-1 / chemistry
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HIV-1 / genetics
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HIV-1 / immunology
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Helminth Proteins / immunology
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Humans
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Immune Sera / immunology
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Integrin beta3
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Molecular Sequence Data
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Oligopeptides / chemical synthesis
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Oligopeptides / immunology
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Peptides / chemistry
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Peptides / immunology
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Platelet Count
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Platelet Membrane Glycoproteins / chemistry
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Platelet Membrane Glycoproteins / genetics*
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Platelet Membrane Glycoproteins / immunology
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Rabbits
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Sequence Homology, Amino Acid
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Serologic Tests
Substances
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Antibodies, Helminth
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Antigens, CD
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Antigens, Helminth
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Epitopes
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HIV Antibodies
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HIV Envelope Protein gp41
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Helminth Proteins
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Immune Sera
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Integrin beta3
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Oligopeptides
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Peptides
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Platelet Membrane Glycoproteins