Abstract
Chromatography of an ethyl acetate extract of seeds of Annona reticulata led to the isolation of a new cytotoxic gamma-lactone acetogenin, cis-/trans-isomurisolenin, along with six known cytotoxic acetogenins, annoreticuin, annoreticuin-9-one, bullatacin, squamocin, cis-/trans-bullatacinone and cis-/trans-murisolinone. Structures of these compounds were established by means of mass and related spectral experiments. Some of the compounds isolated, showed potent cytotoxicities against Hep. 2,2,15, Hep. G2, KB and CCM2, four cancer cell-lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / toxicity
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Carcinoma, Hepatocellular
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Cell Survival / drug effects*
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Colonic Neoplasms
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Furans / chemistry*
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Furans / isolation & purification
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Furans / toxicity
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Humans
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KB Cells
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Lactones / chemistry*
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Lactones / isolation & purification
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Lactones / toxicity
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Plants, Medicinal*
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Seeds*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Furans
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Lactones
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isomurisolenin