Background: The nonpigmenting fixed drug eruption is a distinctive drug reaction characterized by large, tender and symmetric erythematous plaques that disappear with no residual pigmentation.
Methods: A case of a non-pigmenting fixed drug eruption due to pseudoephedrine is reported.
Result: The reappearance of typical lesions at the same sites after oral challenge with 60 mg pseudoephedrine together with the absence of pigmentation confirm the diagnosis.
Conclusion: A new case of proven nonpigmenting fixed drug eruption to pseudoephedrine is described.