Abstract
A patient is described who was treated with tamoxifen for breast cancer and developed an androgen-producing ovarian tumor of low malignant potential, which itself is a rare condition. Clinically overt virilism was leading to the diagnosis and promptly improved after surgical removal of the tumor. A causal relationship between tamoxifen use and the tumor is discussed on the basis of the known tumor-inducing potential of tamoxifen.
MeSH terms
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Androgens / biosynthesis
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Androgens / blood
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Antineoplastic Agents, Hormonal / adverse effects*
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Antineoplastic Agents, Hormonal / therapeutic use
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Breast Neoplasms / drug therapy*
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Epithelium / pathology
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Female
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Humans
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Middle Aged
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Neoplasms, Second Primary / chemically induced*
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Neoplasms, Second Primary / complications
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Neoplasms, Second Primary / pathology
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Ovarian Neoplasms / chemically induced*
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Ovarian Neoplasms / complications*
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Ovarian Neoplasms / pathology
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Tamoxifen / adverse effects*
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Tamoxifen / therapeutic use
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Virilism / blood
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Virilism / etiology*
Substances
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Androgens
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Antineoplastic Agents, Hormonal
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Tamoxifen