Synthetic analogues of netropsin and distamycin. IV. Synthesis of a new carbocyclic analogue of distamycin with alkylating side groups

A Markowska; D Bartulewicz; A Pućkowska; A Rózański

Synthetic analogues of netropsin and distamycin. IV. Synthesis of a new carbocyclic analogue of distamycin with alkylating side groups

Rocz Akad Med Bialymst. 1997;42(1):129-40.

Authors

A Markowska¹, D Bartulewicz, A Pućkowska, A Rózański

Affiliation

¹ Department of Organic Chemistry, Institute of Chemistry, Medical Academy of Białystok.

PMID: 9581472

Abstract

A carbocyclic analogue of distamycin was obtained, in which the N-methylpyrrole rings were substituted by disubstituted benzene rings. Additionally, N-chloro- or N-bromoacetyl groups, displaying alkylating properties, were introduced. The synthesis, starting from 3,5-dinitrobenzoyl chloride, consisted of five stages.

MeSH terms

Alkylating Agents / chemistry
Alkylation
Anti-Bacterial Agents / chemical synthesis*
Antiviral Agents / chemical synthesis*
Benzene / chemistry
Distamycins / chemical synthesis*
Netropsin / analogs & derivatives*
Netropsin / chemical synthesis
Nitrobenzoates / chemistry
Pyrroles / chemistry

Substances

Alkylating Agents
Anti-Bacterial Agents
Antiviral Agents
Distamycins
Nitrobenzoates
Pyrroles
chloroacetyldistamycin
3,5-dinitrobenzoyl chloride
Netropsin
stallimycin
M-bromoacetyldistamycin
Benzene
N-methylpyrrole