Abstract
The effects of intraventricular administration of ethylcholine aziridinium ion (AF64A) were studied in male Wistar rats. Bilateral injections of AF64A (3 nm/3 mcl) reduced the reactions to biological alarm signal and produced a decrease in the open-field activity 3 weeks after this lesion. The lesioned rats also displayed deficit in retention of a passive avoidance task.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aziridines / pharmacology
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Behavior, Animal / drug effects
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Behavior, Animal / physiology*
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Choline / analogs & derivatives
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Choline / pharmacology
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Conditioning, Classical / drug effects
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Conditioning, Classical / physiology
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Escape Reaction / drug effects
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Escape Reaction / physiology
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Extinction, Psychological / physiology
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Hippocampus / drug effects
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Hippocampus / physiology*
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Male
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Nerve Degeneration / chemically induced
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Nerve Degeneration / physiopathology*
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Neurons / drug effects
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Neurons / pathology
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Neurons / physiology*
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Rats
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Rats, Wistar
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Reaction Time / physiology
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Receptors, Cholinergic / drug effects
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Receptors, Cholinergic / physiology*
Substances
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Aziridines
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Receptors, Cholinergic
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ethylcholine aziridinium
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Choline