Abstract
Phytochemical analysis of the fruits of Annona glabra yielded two new kaurane diterpenoids, annoglabasin A (methyl-16 beta-acetoxy-19-al-ent-kauran-17-oate)(1) and annoglabasin B (16 alpha-hydro-19-acetoxy-ent-kauran-17-oic acid)(2), along with 11 known kaurane derivatives (3-13). The structures of the new compounds were established by spectral and chemical evidence. Among these, methyl-16 alpha-hydro-19-al-ent-kauran-17-oate (11) exhibited mild activity against HIV replication in H9 lymphocyte cells, and 16 alpha-17-dihydroxy-ent-kauran-19-oic acid (4) showed significant inhibition of HIV-reverse transcriptase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / isolation & purification
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Anti-HIV Agents / pharmacology
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Carbohydrate Sequence
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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HIV / enzymology
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Humans
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Lymphocytes / drug effects
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Lymphocytes / virology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Sequence Data
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Plants, Medicinal / chemistry*
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Reverse Transcriptase Inhibitors / isolation & purification
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Reverse Transcriptase Inhibitors / pharmacology
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Anti-HIV Agents
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Diterpenes
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Reverse Transcriptase Inhibitors