Abstract
The present study demonstrates that the nitric oxide synthase inhibitor, aminoguanidine, can attenuate the proteinuria observed in a predominantly noninflammatory model of chronic renal disease in the rat. These data suggest that nitric oxide synthase may be involved in progressive renal disease.
MeSH terms
-
Animals
-
Blood Pressure / drug effects
-
Blood Urea Nitrogen
-
Creatinine / blood
-
Enzyme Inhibitors
-
Guanidines / pharmacology
-
Kidney Failure, Chronic / chemically induced
-
Kidney Failure, Chronic / enzymology*
-
Kidney Failure, Chronic / urine
-
Male
-
Nephrectomy
-
Nitric Oxide Synthase / antagonists & inhibitors
-
Nitric Oxide Synthase / metabolism*
-
Proteinuria / enzymology*
-
Rats
-
Rats, Sprague-Dawley
Substances
-
Enzyme Inhibitors
-
Guanidines
-
Creatinine
-
Nitric Oxide Synthase
-
pimagedine